MCM10

A gene on chromosome 10p13 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. MCM10 juxtaposes MCM2-7 helicase and the DNA polymerase alpha/primase complex to initiate DNA replication, and it plays a role preventing DNA damage during replication.

References in periodicals archive

Our other findings considered to be a variant of unknown significance (VOUS) are OPTN, MCM10 and CCDC3 genes CNV duplication at 10p13, GRIP1 gene partial deletion at 12q14.3, CHRNA7 gene partial duplication at 15q13.3, miR128-1, ZRANB3, RHDM3 CNV deletions at 2q21.3 and MACROD2 gene partial deletion at 20p12.1.

Moreover, we identified a 230 kb duplication of 10p13 including OPTN, MCM10, CCDC3 genes in one patient.

Investigation of Copy Number Variation by arrayCGH in Turkish Children and Adolescents Diagnosed with Autism Spectrum Disorders

Lee, "Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins," Proceedings of the National Academy of Sciences of the United States of America, vol.

MCM paradox: abundance of eukaryotic replicative helicases and genomic integrity

Tye, "Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins," Genes and Development, vol.

Molecular signatures of recurrent hepatocellular carcinoma secondary to hepatitis C virus following liver transplantation

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