M40403

A small superoxide dismutase mimetic that removes superoxides, converting toxic free radicals into O2 and H2O2, which are decomposed by catalase. It is being developed as a co-therapy with IL-2 for managing skin and kidney cancers, and has favourable therapeutic effects in animal models of acute myocardial infarction, stroke, inflammatory bowel disease, rheumatoid arthritis, diabetic microangiopathies and septic shock.

Pros
Lower molecular weight than SOD; penetrates cells and membranes easily; more stable; longer half-life; does not trigger an immune response.

References in periodicals archive

Di Paola et al., "Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis," Arthritis & Rheumatology, vol.

Preparation of Keratin-Glycine Metal Complexes and Their Scavenging Activity for Superoxide Anion Radicals

Davidson et al., "Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve," British Journal of Pharmacology, vol.

Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients

Sonis, "Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters," Clinical Cancer Research, vol.

Local and systemic pathogenesis and consequences of regimen-induced inflammatory responses in patients with head and neck cancer receiving chemoradiation

The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation.

Optimize your internal defenses against radiation exposure: will the public heed our warning this time?

Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. Br.

Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats

To counter that side effect, researchers are looking toward M40403, a synthetic enzyme.

Besides reducing IL-2's side effects, M40403 exhibited anticancer activity, reports Wolfram E.

Synthetic enzyme wards off side effects. (Biomedicine: from New Orleans, at a meeting of the American Association for Cancer Research)

Dugo et al., "Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic," Arthritis and Rheumatism, vol.

Therapeutic effects of the superoxide dismutase mimetic compound [Mn.sup.II][Me.sub.2]DO2A on experimental articular pain in rats

Salvemini D, Mazzon E, Dugo I, Riley DP, Serriano L, Caputi AP, Cuzzocrea S (2001) Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. Brit.

Anti-inflammatory and antioxidant effects of Croton celtidifolius bark