References in periodicals archive

TG synthesis impairment was also associated with downregulation of two important enzymes of this pathway: 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (AGPAT2) and the phosphatidate phosphatase LPIN1 (lipin1) in BSCL2 knockdown during adipogenesis [11, 45].

Exploring Seipin: From Biochemistry to Bioinformatics Predictions

The LGZG-treated NAFLD rats exhibited reduced expression of INSIG1 and LPIN1, which indicated the decreased cholesterol biosynthesis and triglyceride accumulation in the liver.

Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion

Many other SNPs of different genes involved in lipid metabolism, such as lipin 1 (LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].

Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study

Gomez et al., "Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus-associated lipodystrophy syndrome," Metabolism, vol.

Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet [beta]-Cell Function in Healthy Individuals

These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).

Systematic and Integrated Analysis Approach to Prioritize Mastitis Resistant Genes

LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.

Ontogenetic expression of Lpin2 and Lpin3 genes and their associations with traits in two breeds of Chinese fat-tailed sheep

Loor, "ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation," The Journal of Nutrition, vol.

PPAR[gamma] regulates genes involved in triacylglycerol synthesis and secretion in mammary gland epithelial cells of dairy goats

Gene Symbol Description FC DLAT Dihydrolipoamide -1,678 S-acetyltransferase HSPB7 Heat shock protein family B -1,422 (small) member 7 LPIN1 Lipin 1 -1,838 MECP2 Methyl-CpG binding protein 2 -1,22 NDUFS3 NADH: ubiquinone oxidoreductase -1,314 core subunit S3 NT5C 5', 3'-nucleotidase, cytosolic -1,524 SIRT5 Sirtuin 5 -1,255 YWHAQ Tyrosine 3-monooxygenase/tryptophan -1,364 5-monooxygenase activation protein theta

Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

The activation of PPAR[alpha] by Wy-14643 resulted in a general increase in lipid metabolism-related genes including several involved in lipid synthesis, such as lipin 1 (LPIN1) and sterol regulatory element binding transcription factor 1 (SREBF1) [28].

Functional role of PPARs in ruminants: potential targets for fine-tuning metabolism during growth and lactation