ITGB2

A gene on chromosome 21q22.3 that encodes an integrin beta chain family protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta chain encoded by ITGB2 can combine with multiple alpha partners to give rise to different integrins—e.g., with the alpha L chain to form the integrin LFA-1, or with the alpha M chain to form the integrin Mac-1. Integrins participate in cell adhesion as well as cell surface-mediated signalling.

Molecular pathology
ITGB2 mutations cause leukocyte adhesion deficiency type I.

Mentioned in

References in periodicals archive

In contrast, the increase in LFA-1 MFI values above the values recorded in healthy Controls with no known exposition to cases of active TB was observed on monocytes from patients with active TB and their healthy contacts but also on monocytes from patients with nonmycobacterial lung disease.

The decreased frequency of monocytes with mCD14 and LFA-1 coexpression in PBML from TB and NMLD patients could have been caused by intensive recruitment of such cells into lungs.

Schlesinger, "Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcyRII and the mannose receptor," Microbiology, vol.

Behar, "'The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection" Journal of Immunology, vol.

Figure 10: The percentage of monocytes designated LFA-1 high ([LFA-1.sup.hi]) and LFA-1 low ([LFA-1.sup.10]) in the study groups.

Monocyte signal transduction receptors in active and latent tuberculosis

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