Medical

KPNB1

KPNB1

A gene on chromosome 17q21.32 that encodes a beta subunit of karyopherin which imports proteins into the nucleus, either alone or in association with an adaptor protein (e.g., an alpha importin subunit).
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References in periodicals archive
Gene-encoding proteins implied that nucleo-cytoplasmic transport was also overexpressed (KPNA2, KPNB1, RANBP1, and RCC1).
Similarly, galectin-1 (Lgals1) appeared to be represented by three clones; karyopherin [beta]1 (Kpnb1) and H3 histone 3B (H3f3b) were represented by two clones each.
The microarray analysis appeared to underestimate the fold change of expression compared with qPCR (Figure 3), with the only exception being Kpnb1, for which a downregulation in embryos was not supported by qPCR (Figure 3).
Although Kpnb1 is a gene whose expression has been reported to be downregulated by HDAC inhibition (Marks et al.
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