KLK6

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins (such as fibronectin, laminin, vitronectin and collagen). It may be involved in regulating axon outgrowth following spinal cord injury. KLK6 may play a role in invasion and metastasis.

Molecular pathology
KLK6 degrades alpha-synuclein, preventing its polymerisation, suggesting a role in the pathogenesis of Parkinson disease and other synucleinopathies.

References in periodicals archive

PPAR[delta] activates PPRE-containing genes associated with metabolism (Olah, Ptgs2, Pla2, and Pld), invasion (Mmp12, Klk6), and inflammation (S100a8/9, Saa1/2/3).

PPAR[delta] as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance

TaqMan gene expression assays used were Hs00160519_m1 (kallikrein 6, KLK6), Hs00173611_m1 (kallikrein 10, KLK10), Hs00234579_m1 (matrix metalloproteinase 9, MMP9) and Hs99999905_m1 (glyceraldehyde 3-phosphate dehydrogenase, GAPDH).

MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma

KLK6, the protein encoded by the Kallikrein-related peptidase 6 (KLK6) [5] gene, is a promising biomarker that is frequently overexpressed at the mRNA and protein levels in tissues and fluids derived from patients with ovarian cancer (OCa) and implicated in a variety of normal physiological processes (3).

Copy number and expression alterations of miRNAs in the ovarian cancer cell line OVCAR-3: impact on kallikrein 6 protein expression

Scarisbrick previously found elevated levels of "KLK6" (a newly identified member of the kallikrein enzyme family) in areas of damage found in tissue samples from people with MS.

Studies of key enzymes

These genes include angiogenic/vascular cell growth factors (VEGF, PLGF, ADM, ANGPT2, TGFB2), vasoactive serine proteases (KLK2, KLK6, KLK9, KLK22), and vascular endothelial receptors (IL17R, BDKRB1, ENG, GNA13).

Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth

The amounts of 18S rRNA and mRNAs encoded by KLK5, KLK6, KLK7, KLK10,

Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer

Recent work has demonstrated roles for KLK5 and 7 in skin desquamation (7), and for KLK6 in the brain (8).

Distribution of 15 human kallikreins in tissues and biological fluids

(30) found no overexpression of the 15 tissue kallikreins in breast cancer tissue compared with healthy breast tissue and down-regulation of the expression of at least 4 tissue kallikrein genes (KLK5, KLK6, KLK8, and KLK10) in breast cancer tissue.

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer

For example, we found that KLK6 and KLK13 have a splice variant with 3'-coding exon 3 extension by ~100 by (close to the length of the retained intron III in the genes examined here).

Intron retention: a common splicing event within the human Kallikrein gene family

The human kallikrein 6 (KLK6)[3] gene, which encodes for hK6 protein, was cloned independently by three groups.

Purification of human kallikrein 6 from biological fluids and identification of its complex with [[alpha].sub.1]-antichymotrypsin