KAT5

A gene on chromosome 11q13 that encodes a catalytic subunit of the NuA4 histone acetyltransferase complex (NuA4 HAC) involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. The NuA4 HAC may be required for activating transcription programmes of oncogene and proto-oncogene mediated growth induction, tumour suppressor-mediated growth arrest/replicative senescence, apoptosis, and DNA repair. Post-translational modifications include sumoylation, phosphorylation, ubiquination and autoacetylation.

References in periodicals archive

Gao et al., "KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma," International Journal of Oncology, vol.

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

* KAT5: Our subsidiary created competencies that were useful in other subsidiaries.

Achieving subsidiary integration in international innovation by managerial "tools"

KAT5 through KAT7, added to the survey in June 2006, were designed to indicate more specifically how many persons not living at their former addresses had returned to them for more than a short period, and to get a sense of how many "normal movers" (people who moved for reasons other than Katrina) the questions may have been picking up.

The current population survey response to Hurricane Katrina: after assessing employee safety and operations hurdles, the Bureau of Labor Statistics and the Census Bureau quickly began collecting new data on hurricane evacuees; jobless rates were sharply lower for those evacuees who returned home than for those who did not

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