Hammadeh et al., "Metastatic juxtaglomerular cell tumor in a 52-year-old man," The American Journal of Surgical Pathology, vol.
Lebel, "A patient with a juxtaglomerular cell tumor with histological vascular invasion," Nature Clinical Practice Nephrology, vol.
Lone, "Recurrent malignant juxtaglomerular cell tumor: A rare cause of malignant hypertension in a child," Journal of Indian Association of Pediatric Surgeons, vol.
Renin, released from juxtaglomerular cells, causes the proteolytic cleavage of angiotensinogen to angiotensin I which is also a target of proteolytic cleavage.
It is generally accepted that the majority of circulating renin originates from the kidney (mainly from juxtaglomerular cells).
Renin is synthesized and secreted into the blood exclusively by the
juxtaglomerular cells of the kidney from prorenin, an inactive precursor, which is produced not only by the kidney, but by other tissues, including the adrenal glands, gonads, and the uteroplacental unit (2).
As a result of direct sympathetic stimulation of the
juxtaglomerular cells and ischemia initiating the rennin-angiotensin cascade, renin and eventually AII are produced.
These granular smooth muscle cells of the afferent arteriole are called
juxtaglomerular cells, which synthesize and store renin, a proteolytic enzyme.