IL12B

A gene on chromosome 5q31.1-q33.1 that encodes interleukin-12B, a cytokine which acts on T and natural killer cells and has a broad array of biological activities; it is expressed by activated macrophages and is an essential inducer of Th1 cell development. IL-12B maintains memory/effector Th1 cells at a level which confers long-term protection against intracellular pathogens. It associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.

Molecular pathology
IL12B overexpression is found in patients with multiple sclerosis; polymorphism of IL12B is associated with an increased risk of asthma in children.

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References in periodicals archive

The upper cervical spinal cord area was (55) associated with disability, linear relationship between 9 loci (BATF, CYP27B1, IL12B, NFKB1, IL7, PLEK, EVI5, TAGAP, nrs669607), inverse relationship with 3 loci (TYK2, RGS1, CLEC16A).

Prognostic-disability Biomarkers in Multiple Sclerosis: Review of the Literature from the Last Five Years/Multipl Skleroz Olgularinda Prognoz-Ozurluluk Biyoisaretcileri: Son Bes Yila Ait Literaturun Gozden Gecirilmesi

Brew, "The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia," HIV Medicine, vol.

IL-1RN and IL-1[beta] Polymorphism and ARV-Associated Hepatotoxicity

The PPI network consists of 27 upregulated proteins including LCK, CD3G, CD3E, CD3D, IFNG, VAV1, TNF, B2M, CXCR3, CCR5, CCL5, CXCL9, CXCL10, CXCR4, GNG2, IL1B, IL12B, IL2RB, IL2RA, IL2RG, STAT1, CD8A, CD86, PTPRC, PIK2CG, CD44, and HLADPA1 and 1 downregulated protein EGF.

LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue

Mendelian Susceptibility to Mycobacterial Diseases MSMD has especially been associated with defects in the IL12B, IL12RB1, IRF8, ISG15, NEMO, IFNGR1, IFNGR2, STAT1, IRF8, and CYBB genes (15-22).

Frequency of Mycobacterium bovis and mycobacteria in primary immunodeficiencies

These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).

Systematic and Integrated Analysis Approach to Prioritize Mastitis Resistant Genes

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

Association of rs11209032 and rs1004819 polymorphisms in interleukin-23 receptor gene with ankylosing spondylitis

Genetic disorders associated with inborn errors in IFN-[gamma]-dependent immunity include those which impair production of IFN-[gamma] (IL12B, IL12RB1, IRF8, ISG15, NEMO) and those which impair response to IFN-[gamma] (IFNGR1, IFNGR2, STAT1, IRF8, CYBB) [2].

Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis--a screen of osteoarticular lesions

Methods: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.

Single Nucleotide Polymorphism rs10919543 in FCGR2A/FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population