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IL-6

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IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

IL-6

IFN-β-2 A glycosylated 22-27 kD cytokine that mediates host response to injury and infection and plays a role in growth and differentiation of B cells, T cells, myelomas, hepatocytes, hematopoietic stem cells and nerve cells; IL-6 is critical for development of IgA-related immunity; IL-6 is a major mediator of the acute phase response–APR, stimulating hepatic production of APR proteins
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive
o IL-1?, IL-1?, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17, MCP-1, TNF-?, MIP-1?, GMCSF, RANTES
Table 4 summarizes the correlation between serum IL-6 and BMI among cases and controls of respective categories.
The study was designed to investigate the effect of smoking on IL-6, an inflammatory marker, and to determine the correlation between SAA-LDL and IL-6 in smokers.
The distribution of genotypic frequencies of IL-6 within the Hardy-Weinberg equilibrium was determined using Pearson's chi-square test.
To evaluate the effect of IL-6 secreted by FLS on Th17 proportion of [CD4.sup.+] T cell, IL-34-stimulated FLS (n = 6) were cocultured by [CD4.sup.+] T cells (n = 6) with treatment of antiCD3 (3, [micro]g/ml)/CD28 (2 [micro]g/ml) antibody and brefeldin A (10 ng/ml)/monension (100 ng/ml) in the presence or absence of IL-6R antagonist (1, [micro]g/ml) (R&D Systems, USA) for 72 h, and single cell suspensions were stained with surface FITC-labeled anti-CD4 (5, [micro]g/ml) (eBioscience, USA) for 30 min and then intracellular stained with APC-labeled anti-IL-17A (5 [micro]g/ml) (eBioscience, USA) for 1 h.
Keywords: COX-2, ELISA, IL-6, Inflammation, Warfarin.
Circulatory IL-6 and tumor necrosis factor - alpha have been shown to be highly significantly associated with chronic periodontitis, as their concentration declined with periodontal treatment.4 Positive affiliation of interleukin-6 in patients with unstable angina5 has also been reported.
IL-6 which is a key substance that mediates inflammatory response in human body is mainly manifested in regulating physiological activities of various immune cells and controlling immune response.
To evaluate the effects of stress hormones on IL-6 secretion, 6 x [10.sup.4] GES-1 cells were seeded into individual wells of a 24-well plate.
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