The SNPs in the
IL-11 promoter region are in complete and/or absolute linkage disequilibrium, so that only three haplotypes (ACC, GCG and GGG) of the possible eight are observed.
Runx2/CBF Mediates inhibition
IL-11 and GM-CSF [30] [beta] of OB are target genes differentiation by of Runx2/CBF[beta] inducing antagonist as OCL activators.
Respiratory syncytial virus induces prostaglandin E2, IL-10 and
IL-11 generationin antigen presenting cells.
IL-11, a pleiotropic cytokine: exciting new effects of
IL-11 on gastrointestinal mucosal biology.
Representative sections of archival, paraffin-embedded material from each of the 5 patients were reacted in immunohistochemical procedures for the detection of the following antigens: [CD.sub.1a], S100 protein,
IL-11, LAP of TGF-[[Beta].sub.1], and angiotensin-converting enzyme (ACE), respectively.
IL-11.
IL-11 is a glycoprotein-130 (GP-130) cytokine that uses the GP-130 signalling pathway that is shared by several cytokines of the same group.
The measure of IL-1[alpha], IL-1[beta], IL-6, IL-8, IL-10, and
IL-11 was performed according to the manufacturer's instructions.
Medical treatments (CSF, EPO or
IL-11) were provided to the patients with myelosuppression.
IL-6, a pleiotropic, proinflammatory cytokine, is the archetypal member of the gp130-related cytokine family, which also includes
IL-11, IL-27, OSM, CNTF, CT-1, LIF, and CLC [68, 69].
The oncogenic cell initiates this pathway by releasing a number of messengers, including cytokines IL-6 and
IL-11, parathyroid hormone-related peptide (PTHrP), and transforming growth factor [beta] (TGF-[beta]).
Gp130 is a common receptor subunit in several other cytokine receptors including the receptors for IL-35 [60], IL-6, Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Cardiotrophin 1 (CT-1), Ciliary Neurotrophic Factor (CNTF), and
IL-11 [61].
Changes in the relative concentration of some cytokines, such as IL-1, IL-6,
IL-11, and IL-19, and transforming-growth -factor-(TGF-) [beta], mediated both directly and indirectly by the tumor stimulate breast cancer proliferation and invasion [1, 7,13].