In our case, the sequence of events was probably development of prerenal failure due to the natriuretic effect of trimethoprim, resulting in further accumulation of trimethoprim and increasing the risk of
hyperkalaemia.
Initially, in addition to treating
hyperkalaemia and acidosis, replacement of salt wasting and rehdyration are also required.
The risk of
hyperkalaemia in ACE-I treated patients is higher in patients with type II diabetes or renal insufficiency.
Bostock, "Nerve excitability changes in chronic renal failure indicate membrane depolarization due to
hyperkalaemia," Brain, vol.
Metoprolol-induced
hyperkalaemia in chronic respiratory acidosis.
The most frequent side effects/symptoms that nurses examined were hypertension (27), hypotension (23), bone disease (20), infection (13), pain (6), feet (6), fatigue (4), pruritus (4), inflammation (4) and
hyperkalaemia (3).
The most common laboratory abnormalities noted among CKD patients were proteinuria, anaemia and
hyperkalaemia. Advancing age, pre-existing morbidities such as diabetes mellitus, hypertension and overweight are characteristics that are strongly associated with the referred CKD patients.
Postoperatively, the patient was transferred to the Intensive Care Unit for 2 days and during his stay developed a metabolic acidosis with multiple episodes of
hyperkalaemia. This was treated medically, and the patient's kidney function returned to baseline.
The takeover will give UK-based Astra-Zeneca access to a drug that could potentially treat the life-threatening condition
hyperkalaemia.
It will give UK-based AstraZeneca access to a drug that could potentially treat the life-threatening condition
hyperkalaemia. The drug, ZS-9, is currently under regulatory review by the US Food and Drug Administration.