Tefinostat or CHR-2845 (cyclopentyl 2-((4-([N.sup.1]hydroxyoctanediamido) cyclohexyl) methylamino)-2-phenylacetate) comes under the
hydroxamic acid category used as a particular substrate for hCE-1 (intracellular carboxyl-esterase), whose expression is limited to cells of the family of monocytes/macrophages.
She added the metal complex of N-aryl
hydroxamic acid are helpful on the breast cancer cell line.
Based on their chemical structures, HDAC inhibitors include short-chain fatty acids,
hydroxamic acids, synthetic benzamides, and cyclic peptides, which exhibit various bioactivities and specificities.
Table 1: Types of epigenetic drugs: Drugs Class 5-aza-cytidine (azacitidine), Nucleoside DNMTIs 5-aza-2-deoxycytidine (decitabine), 5-fluoro-2-deoxycytidine, Zebularine RG108 Non-Nucleoside DNMTIs MG98 Antisense Oligonucleotides Table 2: HDAC inhibitors: Drugs Class Valproic acid, Aliphatic acids Sodium phenylbutyrate, Pivaloyloxymethyl butyrate, Vorinostat Romidepsin Cyclic peptides Belinostat,
Hydroxamic acids Panobinostat Entinostat, Benzamides Mocetinostat
It may be seen that RCP and ACP are competitive to synthetic ion exchange resin showing adsorption capacities of 7.32 and 7.61 mg/g, respectively, which are higher than that of reported value (6.0 mg/g) on resin with
hydroxamic acid ligand [3].
Whiting, "The development and application of ruthenium catalysed oxidations of a
hydroxamic acid and in situ Diels-Alder trapping of the acyl nitroso derivative," Journal of the Chemical Society.
Suberoyl anilide
hydroxamic acid (SAHA) has been through the stages of clinical trials and approved by the U.S.
For many years, numerous and diverse types of HDACi have been identified, including short-chain fatty acids such as valporic acid and phenyl butyrate and
hydroxamic acid derivatives such as suberoylanilide
hydroxamic acid (SAHA), 6-(1,3-dioxo-1H, 3Hbenzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide (termed scriptaid), and trichostatin A (TSA).