Genotype frequencies of RAD51 135 G>C polymorphism in male and female patients with rectal cancer Sex, N (%) Genotype/allele All, N (%) Male Female
Homozygote CC 3 (2.9) 1 (1.4) 2 (6.7)
Homozygote GG 75 (72.8) 55 (75.3) 20 (66.7) Heterozygote GC 25 (24.3) 17 (23.3) 8 (26.7) Total 103 73 (70.9) 30 (29.1) Table 3.
In the present study, all the individuals were divided into three groups according to the results of CYP3A4*1G genotyping, including 143 (71.5%) with wild-type
homozygote (GG), 47 (23.5%) with mutant heterozygote (GA), and 10 (5.0%) with mutant
homozygote (AA).
Results revealed significant differences in the distribution of
homozygote TT genotype between patients with one and three stenotic vessels (p = 0.028), indicating the effect of this polymorphism on the severity of CAD.
The genotypes of 5-HTTLPR were divided into three groups by PCR using specific primers:
homozygote for SS,
homozygote for LL, and heterozygote for LS.
A significant increased risk was identified in the
homozygote model (GG versus AA: OR=1.43, 95% CI 1.06-1.93, [P.sub.H] = 0.27), while no obvious association was observed in other models (G versus A: OR= 1.08, 95% CI 0.96-1.22, [P.sub.H] = 0.75; GA versus AA: OR = 0.86, 95% CI 0.56-1.33, [P.sub.H] < 0.001; GG + GA versus AA: OR = 0.97, 95% CI 0.78-1.20, [P.sub.H] = 0.064; and GG versus GA + AA: OR= 1.28, 95% CI 0.64-2.53, [P.sub.H] = 0.001).
Most of the
homozygote patients had consanguine parents (7 of nine patients).
Rationalizing why faster rates improve genotyping of
homozygotes in small amplicons is more difficult.
In the codominant model of heterozygote vs wild
homozygote, the associations between rs2280091 and rs528557 polymorphisms and asthma in children were significant (OR=1.91, 95%CI=1.24-2.94, and OR=2.92, 95%CI=1.33-6.39, respectively).
-1639 G>A, expressed as VKORC 1 GG, is made up of
homozygote normal (wild) genotypes.
It would be particularly beneficial for animals with long gestation period to save the time required for breeding for the production of
homozygote animals from the verified heterozygotes.
Results: We have detected a new
homozygote mutation of WAS gene (NM_000377.2 p.M393lfs*102(c.1178dupT) in these two patients which was not defined in the literature before.