hemoglobin C

he·mo·glo·bin C

[MIM*141900.0038]

an abnormal Hb with substitution of lysyl residue for glutamyl at the 6th position of the β chain, of formula α₂2^Aβ₂^6Glu→Lys, this type reduces the normal plasticity of erythrocytes. Heterozygotes: Hb C trait, about 28-44% of total Hb is Hb C, no anemia. Homozygotes: nearly all Hb is Hb C, moderate normocytic hemolytic anemia. Patients heterozygous for both Hb C and Hb S (Hb SC disease) and for Hb C and thalassemia are known, and have atypical hemolytic anemias; sickling is enhanced in Hb SC disease.

Farlex Partner Medical Dictionary © Farlex 2012

he·mo·glo·bin C

(Hb C) (hē'mō-glō'bin)

An abnormal hemoglobin that affects the physical properties of erythrocytes, causing hemolytic anemia; often found in patients also having sickle cell disease or thalassemia.
Synonym(s): haemoglobin C.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012