HRAS

A gene on chromosome 11p15.5 belonging to the Ras oncogene family, the protein products of which bind GTP and GDP, have intrinsic GTPase activity, and play key roles in signal transduction. HRAS cycles between de- and re-palmitoylation, a reaction that regulates its rapid exchange between the plasma membrane and the Golgi apparatus.

Molecular pathology
Defects in HRAS are associated with an increased risk of bladder cancer, Hürthle cell carcinoma of thyroid, and oral squamous cell carcinoma. HRAS mutations cause faciocutaneoskeletal syndrome and congenital myopathy with excess of muscle spindles—a variant of Costello syndrome.

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References in periodicals archive

All reported the key to getting members to complete an HRA is finding the right incentives and that the HRA is only the beginning of a broader member conversation.

How plans use risk assessments

The process of implementing online HRAs requires that employers provide electronic eligibility files to the HRA administrators.

Using online health risk assessments: EAPs can help reduce organizational risks by advocating the use of online screening tools as part of a health management program

Employers that offer regular workplace coverage can also set up another type of HRA account -- limited to $1,800 a year -- that will allow workers to get additional benefits such as dental and vision care.

White House expands health accounts aimed at small firms Expands: Accounts will be available next Jan. 1

To be eligible to provide a qualified small employer HRA, an employer must not be an "applicable large employer" (ALE), defined by Sec.

Health reimbursement arrangements for small employers

The guidance further addresses the timing, format, and contents of a required written notification of the HRA to employees, how employees may prove they have minimum essential coverage (with a model attestation document as an appendix), and substantiation requirements for reimbursed medical expenses.

Qualified small employer HRAs get guidance: The IRS answers questions on health reimbursement arrangements, which were reinstated for small employers after PPACA market reform rules generally penalized the popular coverage option

Due to the positive federal income tax and payroll tax treatment of employer contributions to retirees' HRAs, as described in PLR 201528004, these arrangements can be a valuable benefit.

Health reimbursement arrangements

Kura Oncology, a United States-based biopharmaceutical company, has commenced dosing in the Phase II clinical trial of tipifarnib in patients with locally advanced tumours that carry HRAS mutations, it was reported on Tuesday.

Kura Oncology starts dosing in Phase II clinical trial of tipifarnib