This then stimulates
HCN2 gene ion channels, which triggers nerves to auto-fire (like the pacemakers in the heart).
Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel
HCN2 affect the outcome after stroke in mice?
In human, SAN Hcn4 accounts for 75%, Hcn1 for 21%,
Hcn2 for 3%, and Hcn3 for 0.7% of the Hcn in human SAN [53].
Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes
HCN2 and HCN4.
In summary, our results presented that PTZ induced apoptotic neurodegeneration in
HCN2 neuronal cells.
Benndorf, "Elementary functional properties of single
HCN2 channels," Biophysical Journal, vol.
University of Cambridge researchers have isolated a gene called
HCN2, which produces a protein that causes chronic pain.
Summary: British scientists have identified a gene responsible for regulating chronic pain, called
HCN2, and say their discovery should help drug researchers in their search for more effective, targeted pain-killing medicines.
In neonates,
HCN2 and HCN4 subunits are expressed and form channels that are highly sensitive to cAMP and have slower channel dynamics.