Kubota et al., "
Glucokinase and IRS-2 are required for compensatory [beta] cell hyperplasia in response to high-fat diet-induced insulin resistance," Journal of Clinical Investigation, vol.
Evidence from transgenic mice that
glucokinase is rate limiting for glucose utilization in the liver.
If impaired beta cell regulation of [K.sub.ATP] channel activity or
glucokinase activity or HNF activity was the only problem in type 2 diabetes, then its phenotype would resemble that of patients with neonatal diabetes or GCK or HNF mutations, which it does not.
Missense mutations have variable effects on
glucokinase activity ranging from a small change in affinity for glucose to complete inactivity (19).
Immunodetection of
glucokinase (GCK), fructokinase (FK), phosphofructokinase-2 (PFK2), and ACTINB was performed with liver homogenates from each experimental group.
Diabetic rats (group II) showed decreased activity of
glucokinase and increased activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver.
It is suggested that hyperglycemic effect produced is due to mobilization of glycogen in the liver which may be due to direct inhibition of
glucokinase or indirectly by stimulating the release
An altered ability to sense the environment can produce hormone deficiency (e.g.,
glucokinase mutations producing maturity-onset diabetes of the young 2).
Under the terms of the agreement between the companies, Amgen obtained exclusive worldwide rights to Array's small-molecule
glucokinase activator programme, including ARRY-403, which is currently being tested in a Phase I clinical trial in patients with type 2 diabetes.
It may reduce atherosclerotic lesions; and it modifies genomic expressions, for example,
glucokinase. It is an important cofactor to several enzymes, including acetyl CoA carboxylase and other carboxylases.