GPR68

A gene on chromosome 14q31 that encodes a proton-sensing receptor involved in pH homeostasis, which mediates its action by association with G proteins, stimulating inositol phosphate production or Ca2+ mobilisation.

References in periodicals archive

identified a candidate gene GPR68, whose expression products has been implicated in calcium metabolism, for modulating the sensitivity to LEN in MDS cells.

Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation

Recent studies suggest that OGR1-family GPCRs, including OGR1 (GPR68), GPR4, and T cell-death associated gene 8 (TDAG8 or GPR65), also sense extracellular protons and, thereby, stimulates a variety of cellular activities through several types of G proteins [18-21] (Figure 1).

Tiegs et al., "The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH," British Journal of Pharmacology, vol.

Ionotropic and metabotropic proton-sensing receptors involved in airway inflammation in allergic asthma

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