Bukh et al., "Proposed revision to the taxonomy of the genus Pestivirus, family
Flaviviridae," Journal of General Virology, vol.
According to the reports, the NS protein of
Flaviviridae serves principal roles in virus replication and the interaction between hosts and pathogens [6, 7].
Dengue virus exists as four antigenically distinct viruses designated as serotypes (DENV-1 through DENV-4), belonging to genus Flavivirus of family
Flaviviridae. It has a positive-sense RNA genome that is translated as a single polyprotein and post-translationally cleaved into three structural proteins and seven nonstructural proteins (Henchal & Putnak, 1990).
ZIKV itself is a single stranded RNA virus that belongs to the
Flaviviridae family, along with YFV, West Nile Virus, Japanese Encephalitis Virus, and DENV.
As dengue and Zika are both part of the
Flaviviridae family transmitted through a common mosquito host, the researchers wanted to know how vaccinating for one would affect the incidence of the other.
The virus is closely related to other viruses in the family
Flaviviridae such as West Nile, dengue, and yellow fever.
Dengue fever (DF) is the most common acute febrile viral disease among all the arthropod-borne viral diseases caused by a single-stranded RNA virus of
Flaviviridae family.