Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes.
On the other hand, scopoletin increased activation
FoxO1 in this study.
According to the
foxO1 expression profile of human and mouse indicating that miR-133b may be involved in the regulation of
foxO1 in B cell development (Liang et al.
The scientists were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells'
FOXO1 gene.
The ability of the Akt-mediated signaling to dictate changes in muscle size appears to be due, in part, through its influence on the transcription factor
FoxO1. Specifically,
FoxO1, a known target of Akt kinase activity (28), is phosphorylated and subsequently sequestered in the cytoplasm and kept removed from its nuclear target genes upon Akt activation (6,28,35).
One of SIRTl's functions is to deacetylate and activate two proteins called forkhead box protein Ol (
FOXO1) and peroxisome proliferator-activated receptor-[gamma] coactivator 1a (PGC-1[alpha]), a key regulator of energy metabolism.
Active Akt signaling functions to inhibit apoptosis through phosphorylation of proapoptotic factors such as BAD [encoded by BCL2-associated agonist of cell death (BAD)], CASP9 [encoded by caspase 9, apoptosis-related cysteine peptidase (CASP9)], and
FOXO1 [encoded by forkhead box O1 (
FOXO1)].
Foxo1 was also found to be important in regulating the generation of activated Treg cells in the TME.