FGF14

A gene on chromosome 13q34 that encodes fibroblast growth factor 14 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF14’s function is unknown; it is thought to play a role in nervous system development and function.

Molecular pathology
FXF14 mutations cause (autosomal dominant) spinocerebellar ataxia type 27.

Mentioned in

spinocerebellar ataxia type 27

References in periodicals archive

There were also smaller effects on fgf11, fgf14, fgf22, fgfr1, and fgfr4, each of which also displayed either a regionally selective effect or a difference between the two organophosphates.

It is also noteworthy that we saw several important differences in the effects of chlorpyrifos as compared with diazinon: chlorpyrifos decreased fgf2 and fgf11 in the forebrain, whereas diazinon did not; in the brain stem, diazinon reduced fgf2 and induced fgfr4 much more than did chlorpyrifos, and also had effects on forebrain fgf14 and fgfr1 that were not seen with chlorpyrifos.

In addition to the major changes seen for fgf2 and fgf20 expression, we found significant but smaller effects on other members of the FGF superfamily, including fgf11, fgf14, and fgf22, and also on two of the receptor genes, fgfr1 and fgfr4.

Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily

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