A structure seen by light microscopy that recapitulates a normal ependymal cavity, with small central, round to oval lumina, optional cilia and blepharoplasts—distinct basally oriented granular corpuscles in the cytoplasm, which is composed of GFAP and is characteristic of ependymomas

References in periodicals archive

Ependymomas including myxopapillary ependymomas also showed positive staining, mainly in ependymal rosettes. Oligodendrogliomas also showed positivity for GFAP, but in ring-like pattern around nucleus.

GFAP EXPRESSION IN NEUROGLIAL TUMOURS--IMMUNOHISTOCHEMICAL CONFIRMATION FOR DIAGNOSIS AND GRADING

Identifying the presence of perivascular pseudorosettes or true ependymal rosettes is instrumental in the diagnosis.

Clear cell tumors of the central nervous system: a case-based review

No ependymal rosettes, tumor necrosis, or vascular endothelial proliferation is present.

Subependymoma at the foramen of Monro presenting with intermittent hydrocephalus: case report and review of the literature

Ependymomas are characteristically marked by the formation of perivascular pseudorosettes and true ependymal rosettes. Ependymomas stain readily with glial fibrillary acidic protein antibody and do not demonstrate evidence of neuronal differentiation.

Intraventricular mass in a 31-year-old man. (Pathologic Quiz Case)

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Ependymal Rosette