EFNB2

A gene on chromosome 13q33 that encodes ephrin-B2, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNB2 binds to EPHA3, EPHA4, and EPHB4 receptors; with EPHB4 it plays a central role in heart morphogenesis and angiogenesis by regulating cell adhesion and migration. EPHB4-mediated forward signalling controls cellular repulsion and segregation from EFNB2-expressing cells. It may play a role in constraining the orientation of longitudinally projecting axons.

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References in periodicals archive

Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.

Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure

Il10 and Efnb2 genes were also shown to be regulated by miR-27b-3p.

Genes AIRmax pristane FDR AIRmax pristane FDR 120 days/control 170 days/control (FC) (FC) MMP13 10.4 0.001 10.32 0.000587 C5AR1 3.36 0.002 -- -- P2RX7 3.25 0.009 -- -- GPSM3 3.2 0.0003 -- -- C5AR2 3.19 0.004 3.41 0.015568 S1PR1 -3.42 0.000778 -3.63 0.036394 IL-10 -3.93 0.002 -- -- BMP2 -4.31 0.001 -5.11 0.000521 CD69 -6.04 0.002 -- -- EFNB2 -10.24 0.000114 -13.98 0.000003 IL-6 -24.6 0.0002 -15.45 0.003381 TGFB2 -40.36 2.05E--07 -44.4 7.58E--07

miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis

Arteries and arterioles express ephrin B2 (Efnb2) and are negative for Emcn expression.

Structure and Functions of Blood Vessels and Vascular Niches in Bone

According to the published mRNA sequences, mouse Efnb2 (gene access number: NM_010111.5) and Ephb4 (gene access number: NM_001159571.1) genes were synthesized using DNA synthesis technology and overlapping PCR by ThermoFisher Scientific, Inc.

Disturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory Microenvironment

Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.

Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers

High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas.

Expression of EphB4 in head and neck squamous cell carcinoma

For example, they interact with melanocytes, outer root sheath cells, and DP cells via the KIT, EFNB2, and SHH signaling pathways, respectively [31].

Transit-Amplifying Cells in the Fast Lane from Stem Cells towards Differentiation