EFNA1

A gene on chromosome 1q21-q22 that encodes ephrin-A1, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA1 plays an important role in angiogenesis (by RAC1 GTPase activation and vascular endothelial cell migration and assembly) and tumour neovascularisation (by activating EPHA2 and downregulating it). It induces tyrosine phosphorylation, leading to its internalisation and degradation, is induced by TNF and IL1B/interleukin-1 beta, and binds to EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7 receptors.

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References in periodicals archive

The remaining CpGs of the top 10 CpGs annotated to the upstream region of SEMA4G (cg05962511), C19orf66 promoter (cg13480898), EFNA1 (ephrin A1) gene body (cg07207669), SQSTM1 (sequestosome 1) 5'UTR (cg01225779), EML2 (echinoderm 486 microtubule associated protein like 2) gene body (cg06381803), UNKL (unk like zinc finger) TSS200 (cg09183146), MYEOV (myeloma overexpressed) promoter (cg08759026), and SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) 5'UTR (cg17489312).

Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults

I consider change in either overall freedom or change in one of three underlying component scores EFNA1. EFNA2.

TABLE 1 Components of the Economic Freedom of North America Index Area 1 (EFNA1).

Economic freedom and growth in U.S. state-level market incomes at the top and bottom

The genes containing very highly selective SNPs with p-value <0.01 (nearly top 1% SNPs) in all traits and p-value <0.001 (nearly top 0.1%) in any traits were phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2), and ADAM metallopeptidase domain 12 (ADAM12).

The prediction of the expected current selection coefficient of single nucleotide polymorphism associated with Holstein milk yield, fat and protein contents

The EFNA composite index is comprised of three area indices: size of government (EFNA1); distortionary taxation and takings (EFNA2); and labor market freedom (EFNA3).

Columns 2, 3, and 4 report results using each of the three economic freedom areas: size of government (EFNA1), distortionary taxation (EFNA2), and market freedom (EFNA3).

(8) Meanwhile, standard deviation increases in EFNA1 and EFNA2 are associated with an approximately half and third standard deviation increase in income per capita, respectively.

Meanwhile, standard deviation increases in EFNA1 and EFNA2 are associated with approximately half a standard deviation drop in the unemployment rate.

Subnational economic freedom and performance in the United States and Canada