Dow·ney cell
(dow'nē), the atypical lymphocyte of infectious mononucleosis.
Farlex Partner Medical Dictionary © Farlex 2012
atypical lymphocyte
An enlarged dysmorphic lymphocyte characterised by an often irregular monocyte-like nucleus that may stretch the length of the cell, with chromatin strands that parallel the length of the nucleus; nucleoli and azurophilic granules may be present. Atypical lymphocytes are seen in various non-neoplastic conditions, classically in infectious mononucleosis (<20% of circulating WBCs are atypical), toxoplasmosis, CMV infection and viral hepatitis.
ALs were formerly (and arbitrarily) grouped into three types, now of historic interest:
• Type I—Monocyoid or prolymphocytic kidney-shaped or lobulated nuclei, with densely homogeneous hypergranular chromatin, more similar to mature lymphocytes than plasma cells; cytoplasm is bubbly, eccentric and basophilic.
• Type II—Cytoplasmic radiations from the nucleus (“ballerina skirt” cells); cells have 1+ nucleoli; chromatin is less dense and cytoplasm is less foamy than type I, contains some azurophilic granules, is basophilic, and “scallops” around RBCs.
• Type III—Nuclei are coarse, span the cell’s breadth, have clumped red-to-purple chromatin with 1–4 nucleoli; the cytoplasm is abundant, basophilic, and “scallops” around adjacent RBCs. ALs have abundant cytoplasm, with basophilic condensations where they abut RBCs; mitochondria are large, numerous and scattered throughout the cytoplasm.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Dow·ney cell
(dow'nē sel) The atypical lymphocyte of infectious mononucleosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Downey,
H., U.S. hematologist, 1877-1959. Downey cell - the atypical lymphocyte of infectious mononucleosis.
Medical Eponyms © Farlex 2012
Dow·ney cell
(dow'nē sel) The atypical lymphocyte of infectious mononucleosis.
Medical Dictionary for the Dental Professions © Farlex 2012