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Donath-Landsteiner antibody

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Do·nath-Land·stein·er an·ti·bo·dy

(dō'naht-lahnt'shtī-nĕr an'ti-bod-ē)
An IgG antibody associated with paroxysmal cold hemoglobinuria. The antibody is biphasic, reacting with erythrocytes at temperatures lower than 15°C, which fixes complement to the cell membrane. On reaching body temperature, the antibody detaches, but the terminal complement components are activated on the cell membrane, causing hemolysis.
See also: hemoglobinuria
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