- Nashville, Tennessee-based specialty pharmaceutical company Cumberland Pharmaceuticals has expanded its medical specialties to include oncology-related medications with two initial supportive care medications: Ethyol (amifostine) injection and Totect (
dexrazoxane hydrochloride) injection, the company said.
He received
dexrazoxane for cardioprotection prior to each doxorubicin infusion for a total cumulative dose of 6 g/[m.sup.2].
have obtained FDA approval for Totect (
dexrazoxane hydrochloride) in the U.S.
The team also found that
dexrazoxane has proven helpful in preventing many of the cardiotoxic effects of anthracycline treatment, without reducing its anticancer effects.
7 March 2016 - UK-based pharmaceutical and services company Clinigen Group plc (AIM: CLIN) has acquired Totect (
dexrazoxane) from drugmaker Biocodex USA, the company said.
The most promising solution for preventing cardiotoxicity is the coadministration of
dexrazoxane, an iron chelating agent that reduces the formation of anthracycline-iron complexes [20, 21].
Uma possibilidade promissora e o tratamento com
dexrazoxane, um quelante de radicais livres cardioprotetor em adultos que recebem terapia com antraciclicos.
She was then switched to
dexrazoxane, doxorubicin, and ifosfamide, which resulted in a dramatic resolution of the neoplastic lesion.
The drug
dexrazoxane can reduce the occurrence of long-term heart damage in girls undergoing treatment for high-risk acute lymphoblastic leukemia (ALL).
Dexrazoxane reduces the formation of free oxygen radicals induced by the doxorubicin-iron complex and the chronic cardiotoxic effects of doxorubicin in experimental and clinical studies (11), (45).