de·ox·y·ri·bo·nu·cle·ase I

, DNase I [MIM*125505]

an endonuclease that cleaves primarily double-stranded DNA to a mixture of oligodeoxyribonucleotides, each ending in a 5'-phosphate; streptodornase is a similar enzyme. Under appropriate conditions, it can produce single-strand nicks in DNA; used in nick translation and in the mapping of hypersensitive sites.

Synonym(s): pancreatic deoxyribonuclease, thymonuclease

Farlex Partner Medical Dictionary © Farlex 2012

References in periodicals archive

According to the company, Dornase alfa is a recombinant human deoxyribonuclease I (rhDNase I), an enzyme which selectively cleaves deoxyribonucleic acid (DNA).

JHL submits clinical trial application with the Dutch Healthcare Authority for proposed clinical trial of Dornase Alfa Biosimilar in the Netherlands

Deoxyribonuclease I (DNase I; EC 3.1.21.1) is genetically polymorphic (1), and has been postulated to be a candidate molecule for the endonucleolytic activity involved in apoptosis or programmed cell death (2) and involved in the initiation of systemic lupus erythematosus (3).

Human serum deoxyribonuclease I (DNase I) polymorphism: pattern similarities among isozymes from serum, urine, kidney, liver, and pancreas.

An abrupt elevation of the serum deoxyribonuclease I (DNase I) activity in acute myocardial infarction [Abstract].

Rapid quantification of DNase I activity in one-microliter serum samples

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