DPYSL3

A gene on chromosome 5q32 that encodes a member of the collapsin response mediator protein family that forms homotetramers and heterotetramers with CRMP1, DPYSL2, DPYSL4 or DPYSL5, interacting with synaptic vesicle protein 2 and SH3A domain of intersectin. DPYSL3 is necessary for signalling by class-3 semaphorins and subsequent cytoskeletal remodelling; it plays a role in axon guidance, neuronal growth cone collapse and cell migration.

Mentioned in

DYRK2

References in periodicals archive

Ohshima, "Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish," Developmental Biology, vol.

CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons

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