DLG5
DLG5
A gene on chromosome 10q23 that encodes a protein of the membrane-associated guanylate kinase (MAGUK) family, the members of which have a catalytically inactive guanylate kinase domain, PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. DLG5 localises to the plasma membrane, interacts with components of adherens junctions and the cytoskeleton, and may be involved in transmitting extracellular signals to the cytoskeleton and maintaining epithelial cell structure.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Franke et al., "Genetic association of
DLG5 R30Q with familial and sporadic inflammatory bowel disease in men," Disease Markers, vol.
Two additional loci have been associated with susceptibility to IBD: the discs large homolog 5 gene (
DLG5) and the IBD5 locus on 5q31 (IBD5).
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