DDB1

A gene on chromosome 11q12-q13 that encodes the large subunit of DNA damage-binding protein (a heterodimer composed of a large and a small (DDB2) subunit) that functions in nucleotide-excision repair.

Molecular pathology
DDB1 mutations have been tentatively linked xeroderma pigmentosum complementation group E (XPE).

Mentioned in

References in periodicals archive

On chromosome 6 there are several protein coding sequences in near vicinity of the locus rs109210955, including leucine aminopeptidase (LAP3), mediator of RNA polymerase II transcription subunit 28 (MED28), family with sequence similarity 184 member B (FAM184B), DDB1 and CUL4 associated factor 16 (DCAF16), non-SMC condensin I complex subunit G (NCAPG), ligand-dependent nuclear receptor corepressor-like protein (LCORL).

Effect of single nucleotide polymorphisms on intramuscular fat content in Hungarian Simmental cattle

Patients whose tumors had gains containing the BIRC5 gene and the DNA damage-binding protein (DDB1) gene (11q12.2) had inferior survival, but the study was limited to small numbers of patients.

Anaplastic large cell lymphoma: twenty-five years of discovery

CRBN interacts with the DNA damage-binding protein-1 (DDB1), Cullin 4 (Cul4A or Cul4B), and regulator of Cullins 1 (RoC1) to form the functional E3 ubiquitin ligase complex.

Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation

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