Biliverdin reductase: a major physiologic
cytoprotectant. Proc.
Biliverdin reductase, a major physiologic
cytoprotectant, suppresses experimental autoimmune encephalomyelitis.
Bilirubin represents a lipophilic
cytoprotectant antioxidant which is complementary to water-soluble antioxidants, such as GSH [29].
Chong, "Nicotinamide: necessary nutrient emerges as a novel
cytoprotectant for the brain," Trends in Pharmacological Sciences, vol.
Therefore, standard medical management of GUE comprises antacids, proton pump inhibitors, [H.sub.2]-receptor antagonists, and
cytoprotectant drugs.
ERGO provides several physiological benefits such as a
cytoprotectant, enhancement of metabolic energy, protection against formation of cataracts, molecular regulation of antiinflamatory mechanisms in lungs, etc.
In the present study, the protection of LECs by estrogens might be due to their potent
cytoprotectant mechanisms evidenced by decrease in ROS production and increase in cell viability.
In addition sucralfate promotes the local production of prostaglandins, which acts as a
cytoprotectant stimulating epithelial proliferation, migration, blood flow and mucus production.
Metallothionein acts as a
cytoprotectant against doxorubicin toxicity.