Provention's development pipeline includes a Phase 3 candidate for the interception of type 1 diabetes, two Phase 2, clinical-stage immunology candidates for inflammatory bowel diseases, a Phase 1 candidate for auto-antibody-mediated diseases such as systemic lupus erythematosus, and an investigational new drug -enabling-stage vaccine for acute
coxsackie B virus infection and the potential prevention or delay in onset of T1D.
Its pipeline includes a Phase 3 candidate to treat type 1 diabetes, a drug that is in Phase 2 clinical trials to treat inflammatory bowel disease and an investigational new drug developed to treat acute
coxsackie B virus infection and the potential prevention or delay in onset of type 1 diabetes.View the full article from NJBIZ at http://www.njbiz.com/article/20180720/NJBIZ01/180729989/oldwick-biopharma-company-raises-64m-in-ipo.
antibody in the diagnosis of enteroviruses, and the significance of coinfection with multiple serotypes of
Coxsackie B virus.
Bell, [12] found that 1/3rd cases of pericarditis and % cases of myocarditis were associated with Coxsackie B virus infection.
Adult heart disease due to Coxsackie B virus. Medicine (Baltimore) 1968;47(2):133-47.
Streptococcus M protein and
coxsackie B virus have epitopes that are immunologically similar to cardiac myosin and so, during and after the viral infection, the immune system may attack cardiac myosin.
The patients' IgM and IgG turned out positive for
Coxsackie B virus by ELISA.
Hober-Vandenberghe et al., "Detection of
coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus," Journal of Medical Virology, vol.
Belinda Linden, a cardiac nurse adviser at the British Heart Foundation, said some people with the
Coxsackie B virus suffered flu-like symptoms and then recovered, while others suffered long-term damage to the heart.
An ELISA (Virion/Serion, Wurzburg, Germany) detected IgG antibodies for rubella virus, cytomegalovirus, varicella zoster virus, parainfluenza virus, adenovirus, and
coxsackie B virus; however, these results were not indicative of active infection.
Most EVs have been implicated in aseptic meningitis, most notably echovirus (E) 30, 9, 6, and 11 and
coxsackie B virus (CBV) type 5 (2); other serotypes are less frequently associated with neurologic disease.