Medical

Cowden's Syndrome

A rare autosomal dominant hamartoma/neoplasia syndrome [MIM 158350] characterised by multiple hamartomas—which arise from all three germ cell layers, most prominently from the ectoderm and endoderm, in particular hamartomas of skin and the GI tract, from the stomach to the colon—and an increased risk of developing cancer, including the breast, thyroid, and uterus. Women with Cowden’s syndrome have up to a 50% lifetime risk of developing breast cancer and up to 75% have benign breast disease—fibroadenomas, fibrocystic changes
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in
References in periodicals archive
Barwell, "Cowden's syndrome with immunodeficiency," Journal of Medical Genetics, vol.
De Novo PTEN Mutation in a Young Boy with Cutaneous Vasculitis
Cowden syndrome is a serious genetic disorder characterized by multiple hemartomas usually of skin, but also of thyroid, G.I tract, Bones, CNS, Eyes and G.U tract Cowden's syndrome is considered part of PTEN hemartomas tumor syndrome (PHTS) which also includes Bannyan--Riley --Ruvalcaba syndrome, proteus syndrome, and proteus--like syndrome.
A rare case of vascular hamartoma in neck of a 50 year male
The dermatopathology of Cowden's syndrome. Br J Dermatol.
Molecular Pathology of Skin Neoplasms of the Head and Neck
In patients with Cowden's syndrome, retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's thyroiditis, and inflammatory pseudotumor of the orbit can all manifest, either alone or in combination.
Cowden's disease with vocal fold involvement
Cowden's syndrome (Multiple Hamartoma Syndrome): This rare condition is characterized by the presence of gastro intestinal, oral and cutaneous hamartomas and neoplasms of the breast and thyroid.
Solitary villo adenomatous polyp with carcinomatous changes--rectum: a case report
Cowden's syndrome is considered part of PTEN hemartomas tumor syndrome (PHTS) which also includes Bannyan--Riley --Ruval caba syndrome, proteus syndrome, and proteus--like syndrome.
A case of vascular hamartoma of neck in 8 year old boy
Copyright © 2003-2025 Farlex, Inc Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.