CASP12

A pseudogene on chromosome 11q22.3 that encodes a protein which lacks protease activity. CASP12 may reduce cytokine release in response to bacterial lipopolysaccharide during infection and downregulate activation of NF-kappa-B in response to TNF.

References in periodicals archive

After blocking, the PVDF membranes were incubated overnight at 4[degrees]C with IRE1[alpha] (1:800), p-IRE1[alpha] (1:600), caspase 12 (1:800), C/EBP homologous protein (CHOP, 1:1000), and 78 kDa glucose-regulated protein (GRP78, 1:1000), all rabbit antibodies (CST, USA).

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

Recently, a mechanism of signaling for programmed cell death was described which requires the activation of caspase 12. In mice, caspase 12 appears to be localized to endoplasmic reticulum (ER), and is activated in response to stimuli by which ER became stressed and release the calcium stored (Nakagawa et al., 2000).

Excretion products of Shigella dysenteriae and apoptotic cell death on chick embryo muscle tissue/Producto de excrecion de Shigella dysenteriae y la muerte celular por apoptosis en tejido muscular de embrion de pollo

This novel observation associated with the benzene toxicity mechanism together with the downmodulation of caspase 12 was similarly addressed using WT and p53-KO mice in the study of the mechanism of chronic obstructive urinary disturbances (Choi et al.

Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.