Cao et al., "Allene oxide cyclase from
camptotheca acuminata improves tolerance against low temperature and salt stress in tobacco and bacteria," Molecular Biotechnology, vol.
Zu et al., "Design and performance evaluation of ionic liquids-microwave based environmental-friendly extraction technique for camptothecin and 10-hydroxycamptothecin from samara of
Camptotheca acuminate," Industrial & Engineering Chemistry Research, vol.
It has been used to extract camptothecin and hydroxycamptothecin from
Camptotheca acuminata leaves [17] and isoflavones from soybean meal [18], which has been proved to be an effective extraction method.
Camptothecin (CPT), a modified monoterpene indole alkaloid, was isolated for the first time from
Camptotheca acuminate (Sirikantaramas et al., 2008).
Some important examples of naturally derived anticancer compounds are Vincristine and Vinblastine from Catharanthus roseus, Paclitaxel from Taxus brevifolia, and Topotecan and Irinotecan from
Camptotheca acuminata [2, 3].
Trifolin is found in many plants, such as Diospyros blancoi (Candolle, 1844),
Camptotheca acuminata (Perdue, 1966), Euphorbia condylocarpa (Roshchin, 1977), and Consolida oliveriana (Arboretum, 1967).
Chemists are trying now to synthesize the substance, whose only known natural source is the rare
Camptotheca acuminata tree.