We also found that the endometrial expression of LIFR was greatest on day 15 of pregnancy, when the implanting conceptus produces the large amounts of cytokines such as interferons (IFNs), IFN-[gamma], and IFN-[delta] [25], and the endometrium produces cytokines and chemokines such as cysteine-X-cysteine motif chemokine ligand (CXCL) 9, CXCL10, and
CXCL11 [29].
The involvement of
CXCL11 in bone marrow-derived mesenchymal stem cell migration through human brain microvascular endothelial cells.
(10,42,64) This was initially discovered by Watanabe et al., who found that gastric and colon cancer cell lines produced a large amount of chemokines upon stimulation with NOD1 ligand and that these included chemokines with the C-X-C motif (CXCL9, CXCL10, and
CXCL11) that are dependent on type I IFN responses.
(5) In TB disease, Th17 primarily exerts its protective effect through IL-17, which recruits neutrophils to promote granuloma formation, (6) and increases the expression of chemokines, CXCL9, CXCL10, and
CXCL11, which recruit IFN-[gamma] producing cells to the infected site.
Interleukins [interleukin 8 (IL8), interleukin 6 signal transducer (IL6ST), interleukin 7 (IL7), interleukin 15 (IL15), and interleukin 1 receptor type 1 (IL1R1)] and chemokines [C-X-C motif chemokine ligand 2 (CXCL2), C-X-C motif chemokine ligand 6 (CXCL6), C-X-C motif chemokine ligand 10 (CXCL10), C-X-C motif chemokine ligand 11 (
CXCL11), C-C motif chemokine ligand 5 (CCL5), and C-C motif chemokine ligand 28 (CCL28)] also were overexpressed in HT-29 cells.
Fallahi, "Increase of interferon-gamma inducible CXCL9 and
CXCL11 serum levels in patients with active Graves' disease and modulation by methimazole therapy," Thyroid, vol.
Here in our study, we aim to explore the effect of antiviral treatment of CHC patients with DAAs on the frequency of monocytes (classic [CD14.sup.++][CD16.sup.-] monocytes and inflammatory [CD14.sup.+][CD16.sup.+] monocytes) [18], NK cells ([CD3.sup.-][CD16.sup.+][CD56.sup.+]) [19], and cytokines IL-12, IL-18, CXCL10, and
CXCL11, which are necessary to activation of NK cells, and soluble CD14 (sCD14) and soluble CD163 (sCD163), which reflect monocytes activation.