Mentioned in

References in periodicals archive

However, the pitfall for such conventional drugs has been obvious --they block both COX-1 and COX2, and they also lead to a persistent "rebound effect" on pro-inflammatory factors.

Herbal coxibs: the future of pain relief

In 2005 the FDA issued a Public Health Advisory informing prescribes to "use the lowest effective dose for the shortest duration consistent with individual patient treatment goals." (17) Whereas attempts have been made to mitigate the risk of NSAIDs through enteric coating, pro-drug formulations, agents with less selectivity for COX-1 and combination products to reduce upper GI complications, none of these approaches has provided an overall dose reduction in the formulation of NSAIDs.

Optimizing NSAID management

After a preliminary screening, the red wines were diluted in ratio 1: 9 in water to reach the final concentration of 5 mL/L and white wines were tested undiluted resulting in a concentration of 50 mL/L for the COX-1 and COX-2 assays.

Impact of wines and wine constituents on cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase catalytic activity

To further explore the structural characters of the COX-1/COX-2-alpha-Patchouli alcohol isomer complexes, molecular docking, molecular dynamics simulations, and MM-PBSA (molecular mechanical and poisson born/surface accessible) binding-free-energy calculations were performed on COX-1 and COX-2 systems in complexes with alpha-Patchouli alcohol isomers (CID442384, CID521903, CID6432585, CID3080622, CID10955174, and CID56928117).

Binding energy calculation of Patchouli alcohol isomer cyclooxygenase complexes suggested as COX-1/COX-2 selective inhibitor

A COX-1 desempenha um papel importante na manutencao das funcoes normais em nivel vascular, gastrico e renal, catalisando a formacao de prostanoides de protecao.

The sale's evaluation of drugs partially selectives to COX-2/Avaliacao da dispensacao de farmacos parcialmente seletivos para COX-2

We examined the expression of COX-1 and COX-2 of the whole kidney.

Alteration of renal cyclooxygenase expression due to partial unilateral ureteral obstruction in neonatal

Older NSAIDs include drugs like Naprosyn, which inhibits mostly COX-1; Advil, which inhibits COX-1 and COX-2; and Voltaren and Mobic, which mostly inhibit COX-2.

How pain medication Vioxx ups heart disease risk

A prostaglandina sintetase - 1 (Cox-1) e uma enzima constitutiva, geralmente expressa nos tecidos (6).

The contribution of coxibs therapy in small animals oncology/ A contribuicao da terapia com coxibes na oncologia de pequenos animais/ La contribucion del terapia con coxib en oncologia de los pequenos animales

Within the vascular lumen, COX-1 and COX-2 play an important role in the interaction between platelets and endothelial cells and in thrombogenesis.

Non-steroidal anti-inflammatory drugs and cardiovascular risk

Blocking the COX-2 enzyme relieves inflammation and pain, but blocking COX-1 can increase the risk of stomach ulcers and bleeding.

Best drug for arthritis carries heart attack risk