CDH11

A gene on chromosome 16q21 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH11 is a so-called type-II (atypical) cadherin—which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins—and is expressed in osteoblastic cell lines. It is upregulated during differentiation, suggesting a role during in bone development and maintenance.

Molecular pathology
Defects in CDH11 commonly occur in aneurysmal bone cysts and consist of a translocation t(16;17)(q22;p13) with USP6.

Mentioned in

References in periodicals archive

USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.

Nonneoplastic lesions that simulate primary tumors of bone

Andreadis, "CDH2 and CDH11 act as regulators of stem cell fate decisions," Stem Cell Research, vol.

Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

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