CM-101, is a fully humanised monoclonal antibody targeting the chemokine
CCL24 that is in clinical development for the treatment of patients with liver fibrotic diseases such as NASH and Primary Sclerosing Cholangitis.
GM-CSF is basically a hematopoietic and myelopoietic growth factor (17,18) which also promotes production of pro-inflammatory cytokines such as 'TNF-[alpha], IL-6, IL-12p70, IL-23 and IL-1[beta] as well as chemokines like CCL22,
CCL24, CCL5 and CCL1 which promote leukocyte recruitment' (17).
The current study reports on the gene expression and molecular characteristics of three members of the CC family of chemokines: 1) dual chemokine ligand CCL17; 2) homeostatic chemokines ligand CCL21; and 3)
CCL24 in response to bacterial challenge in large yellow croaker (Larimichthys crocea).
Eotaxin2 (
CCL24), a member of the CC chemokine family, is a potent chemoattractant for eosinophils, basophils, and lymphocytes, distributed in a variety of tissues, including human brain [15].
[14] A higher transcription of both Chemokine Ligands (
CCL24) as well as Chemokine Receptors (CCR6) have been reported recently in major depressive disorders.
ACKR2 binds most inflammatory CC-chemokines (CCL2, CCL5, CCL3, CCL4, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, and
CCL24) leading to their degradation, thereby reducing local levels of inflammatory chemokines.
genes de quimiocinas CCL5/RANTES, CCL11,
CCL24, CCL26, filagrina e outros) e (d) associados a funcao pulmonar e remodelamento bronquico (ADAM-33, DPP-10 e HLA-G, dentre outros).
The company's lead investigational drug candidate, CM-101, is targeting the chemokine
CCL24, an important driver of fibrotic processes.
T cells and inflammatory tracheal epithelial cells released more eotaxins (CCL11 and
CCL24) to induce mature eosinophil migration into the airways.