CARD8

A gene on chromosome 19q13.33 that encodes a protein involved in apoptosis which is highly expressed in the lung, ovary, testis and placenta. CARD8 inhibits NF-kappa-B activation and regulates cell responses controlled by NF-kappa-B transcription factor. It may be part of the inflammasome, a protein complex that activates proinflammatory caspases.

Mentioned in

cardinal

References in periodicals archive

Many studies have uncovered the performance of the CARD8 gene polymorphism rs2043211 in autoimmune disorders, RA, CD, and IBD [13,14,42,43].

Rantapaa-Dahlqvist, "CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.

Ahmad et al., "TUCAN (CARD8) genetic variants and inflammatory bowel disease," Gastroenterology, vol.

NF-[kappa]B-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia

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