C5

C5

A diagnostic category based on the NHSBSP guidelines for reporting fine needle aspiration cytology of breast lesions. C5 aspirates are adequate and contain cells with features that are frankly malignant; some centres divide them into C5a (carcinoma in situ) and C5b (invasive carcinoma). The smears are usually highly cellular with single or dissociated clusters of malignant cells, with increased nuclear:cytoplasmic ratio, markedly pleomorphic cells with hyperchromatic nuclei, prominent nucleoli, irregular nuclear membrane and chromatin, and often a necrotic background.

Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

complement deficiency

A state in which any of the complement proteins is subnormal

Complement deficiencies–associated disorders

C1

C1r    SLE, renal disease, repeated infections

C1s    SLE

C2    SLE, vasculitis, membranoproliferative glomerulonephritis, dermatomyositis

C3 Repeated infections

C4 SLE

C5 SLE, gonococcal disease

C6 Relapsing meningococcal meningitis, gonococcal infection

C7 Raynaud's disease, chronic renal disease, gonococcal infection

C8 SLE, gonococcal infection

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.