Adhesion molecules/ growth factors, including ciliary neurotropic factor (CNTF), epidermal growth factor (EGF), intercellular adhesion molecule (ICAM1), insulin-like growth factor binding proteins (IGFBP4), and bone morphogenetics protein (
BMP6), were also stimulated in the preeclamptic placenta (Fig.
found that the impairment of immunoregulatory function in MSCs from Sjogren's syndrome was because of the higher expression of
BMP6. Their result showed that
BMP6 could downregulate PGE2 secretion from MSCs via Id1 (inhibitor of DNA-binding protein 1); neutralizing
BMP6 and knockdown of Id1 could restore the BMMSC immunosuppressive function both in vitro and in vivo.
Signal transduction TSC2, SOCS3 mTOR, SHIP1, SOCS1, molecules: Notch PDL-1, CD163, CD204, CD206, CD301, IRAK- M Ron, TRAF-2, Rock2 Soluble mediators IL-12, TNF-a, Gas6 IL-1, IL-4, IL-6, (cytokines, growth CXCL9, CXCL10, IL-10, L-33, IL-34, factors): CXCL11 TGF-[alpha], CSF-1 Ym1, Fizz1, SDF-1, WNT5A, WNT7B,
BMP6 CCL1, CCL2, CCL17, CCL18, CCL22, CCL24, CXCL8, CXCL12 Transcription NF-kB p65/p50 NF-[kappa]B p50- factors: STAT1 p50, STAT3, STAT6, PPAR[gamma] RORC1- ROR[gamma], HIF-1, HIF-2, IRF4 miRNAs: miR-155, miR-33 miR-146a, miRNA let 7b, miR-223