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BCR

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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
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References in periodicals archive
The problem with the BCR formula proposed by the ATC is that it is the formula for the net benefit investment ratio (NBIR) (Campbell and Brown 2003; Perkins 1994).
"It is the sale of the Bell Centre and the winding up of BCR as a charity, meeting the requirements of the Charity Commission, and the payment of all debts which is the priority for the trustees.
In 2010, BCR, majority owned by Austria's Erste, rose to the top spot in the SEE TOP 100 Banks ranking after being the runner-up in 2009.
Which of the following is MOST suspicious of a BCR diagnosis?
As an example it could be mentioned the card issues: BCR had almost 1,338,461 issued units while RFZ came with only 431,356 units, where the main influence factor had been the sale forces that according to the number criteria were in favor of BCR even though the card issuing time was favorable to RFZ (several days instead of a week).
These remittances were quite strong during 2005, according to the BCR, which reported that remittances totaled us$2.8 billion.
''Banks do not install ATMs in blocks of flats,'' BCR spokesman Cornel Cojocaru said.
En el cromososma 22 se encuentra la region bcr (breakpoint cluster region), denominada tambien gen BCR, en el cual se puede distinguir la region mayor (M-bcr) entre los exones 12 al 16, (originalmente descritos como exones b1-b5), la region menor (m-bcr) ubicada entre los exones e2' y e2 y la micro region (u-bcr) ubicada en el exon 19 (Heisterkamp et al., 1985; Deininger et al., 2000; Laurent et al., 2001).
New data from several sources--including the National Cancer Institute, the journal Breast Cancer Research (BCR), and a report released by The Breast Cancer Fund and Breast Cancer Action--have advocates calling for more studies of the possible link between environmental factors and increased rates of breast cancer.
Chemetall plc has recently announced a new addition to its UK manufactured product range, with the introduction of Oakite BCR (buffing compound remover).
(4.) Goran Vezic, "Croatian Extremists on the March", Balkan Crisis Report (Institute of War And Peace Reporting) May, 16 2000: http://www.iwpr.ac.psiweb.com/index.p15?archive/bcr/ bcr 20000516 1 eng.txt.
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