These new resources may thus facilitate the application of
August Krogh's longstanding principle, "For many problems there is an animal on which it can be most conveniently studied" (Krogh, 1929.
In 1923 Nobel-prize winning physiologist
August Krogh was granted permission from Banting and Best to produce insulin in Denmark, founding Nordisk Insulinlaboratorium--the company now known as Novo Nordisk.
This time, the history leads me to Copenhagen, Denmark and the remarkable scientist and gifted instrument builder,
August Krogh. While there is no clear evidence that he thought in terms of a well defined physiological intensity "threshold", he was clearly interested in exercise metabolism as a function of work rate.
Professor
August Krogh (1874-1949) of the University of Copenhagen, the most recent winner of the Nobel Prize in Physiology or Medicine in 1920 "for his discovery of the capillary motor regulatory mechanism" during exercise, had come to the US to deliver the Silliman Lecture at Yale.