Pegzilarginase is an enhanced human
arginase that enzymatically depletes the amino acid arginine.
Enzyme abbreviations are as follows: ADC, arginine decarboxylase; ARG,
arginase; GAD, glutamate decarboxylase; NOS, NO synthase; ODC, ornithine decarboxylase; P5CR, pyrroline-5-carboxylate reductase; P5CS, pyrroline-5-carboxylate synthetase.
From the foregoing, it can be concluded that the use of
arginase inhibitors is necessary to increase the production of nitric oxide, which helps prevent the formation of endothelial dysfunction.
Kuo, "Macrophage
arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity," Cancer Research, vol.
Quantification of Nitric Oxide,
Arginase Activity, and IL-10.
After many doctor visits, lots of tests, and months of fear, a Metabolic Specialist diagnosed me with a rare genetic defect,
arginase deficiency, a part of the urea cycle group of birth defects.
Manganese homeostasis is of great importance to the organism because it is an essential mineral for the activity of several enzymes such as pyruvate carboxylase, which catalyzes the conversion of pyruvate to oxaloacetate (16);
arginase, which converts arginine to urea (17); and manganese superoxide dismutase (MnSOD), critical for antioxidant defense (18).
In addition, haemolysis releases
Arginase, which degrades Arginine the substrate for endothelial NO synthase resulting in decreased NO production.