Devreese, "Automated indirect immunofluorescence microscopy enables the implementation of a quantitative internal quality control system for
anti-nuclear antibody (ANA) analysis," Clinical Chemistry and Laboratory Medicine, vol.
Labs at diagnosis of antagonist-induced lupus-like syndromes Serological marker Result
Anti-nuclear antibody 1:640 (previously 1:160 @ [RA.sup.+] diagnosis) Anti-SSA antibody Positive Anti-dsDNA antibody 14 IU/mL Anti-Smith antibody Negative Anti-Histone antibody 1.9 U Anti-Chromatin antibody Positive C3 (80-178 mg/dL) 85 mg/dL C4 (12-42 mg/dL) 13 mg/dL Anti-SSA antibody: Anti-Sjogren's-syndrome-related antigen A; Anti-dsDNA: Anti-doublestranded deoxyribonucleic acid; RA: Rheumatoid arthritis; C3: Complement component 3; C4: Complement component 4
Laboratory studies can show leukopenia, neutropenia (including agranulocytosis), elevated erythrocyte sedimentation rate, normal coagulation studies, and positive autoantibodies including p- and cANCA,
anti-nuclear antibody, and lupus anticoagulant.
Rose-Waaler (RWT),
Anti-Nuclear Antibody (ANA), Anti-Thyroglobulin
Typically, detection of autoantibodies directed against extractable nuclear antigen's (ENA) is a second-round set of analyses following a reactive
anti-nuclear antibody (ANA) test.
Anti-nuclear antibody was absent, rheumatoid factor was negative, complement 3 (83 mg/dl, normal: 77-195) and complement 4 (25 mg/dl, normal: 7-40) levels were normal.
Only a few cases of the prozone phenomenon for
anti-nuclear antibody detection have been described.
(21,22) She matched 4 of the 11 criteria of psychosis (neurologic disorder); positive
anti-nuclear antibody test; thrombocytopenia and hypocomplementaemia with low C3 (haematologic disorder); and positive antiphospholipid antibody test (immunologic disorder).
Indicators of nonspecific inflammation and autoimmune activity, such as C-reactive protein, rheumatoid factor, and
anti-nuclear antibody titers were within normal limits.
These include examinations for L.E.,
anti-nuclear antibody (ANA), and serum complement (a protein that is decreased during active phases of autoimmune illness).
The test for
anti-nuclear antibody was positive at 80 folds for homogeneous and speckled pattern (normal range <40 folds); however, the results for anti-topoisomerase, anti-centromere, anti-ribonucleoprotein, anti-ribonucleic acid polymerase III, and anti-Sjogren syndrome antigen A/Ro and anti-Sjogren syndrome antigen B/La antibodies were all negative.