Anaplasia in pilocytic astrocytoma predicts aggressive behavior.
Microscopically; mucosa revealed diffuse urothelial dysplasia with loss of polarity, nuclear atypia; and carcinoma in situ with irregular nuclear crowding, nuclear
anaplasia and mitosis, involving entire thickness of the epithelial layer.
He describes how gene mutations are not powerful enough to cause cancer; how cancer is initiated and why progression takes years or decades; and the global or macroscopic characteristics that identify cancer:
anaplasia, autonomous growth, metastasis, abnormal cell morphology, DNA indices from 0.5 to over 2, genetic instability, and the high level of membrane-bound and secreted proteins responsible for invasiveness and loss of contact inhibition.
The animals showed a marked degree of hyperplasia with mitotic figure in the cells of stratum granulosum of epidermis and fibrocytes of the dermis, extensive
anaplasia and malignant changes in acini and ducts of the mammary gland.
Histologically, diffuse
anaplasia, PAS positive-DR hyaline globules and variable myxoid change.
Ha elevado pleomorfismo celular e nuclear associado com intensa
anaplasia. O indice mitotico e elevado, com 3 a 4 figuras de mitose por campo de grande aumento.
Prognostic histology may be divided into favourable histology (triphasic Wilms' tumour and cystic, partially differentiated nephroblastoma) and unfavourable histology (focal or diffuse
anaplasia, and cells that are more abnormal and appear bizarre with large and distorted nuclei).
Histologically, these tumors usually demonstrate definitive
anaplasia, although sometimes the distinction between a periosteal chondroma and low-grade chondrosarcoma is difficult or indeterminate.
Anaplasia with cell pleomorphism and varying degrees of mitotic activity are characteristic for all malignant variants except the dendritic and whorled types (WEISS & FRESE, 1974).
Nevertheless, a few studies have documented minor his top a tho logical differences between AIDS-associated KS and non-HIV associated KS cases [14-16]: lesional cell mitoses and cellular
anaplasia are surprisingly more common in HIV-negative patients, whereas KS lesions in HIV-positive patients tend to display more extensive dissecting vessels.
Grade III (anaplastic) meningiomas are characterized by
anaplasia, brain invasion, and [greater than or equal to] 20 mitoses per 10 HPF or are of the rhabdoid or papillary subtypes (Perry et al., 1999).
Las evaluaciones histopatologicas microscopicas permitieron revelar la presencia de tejido neoplasico maligno poco diferenciado de tipo linfoide, con predominio de linfocitos B con alto grado de
anaplasia y areas de necrosis con hemorragias, ratificando el diagnostico de linfosarcoma multicentrico: Las celulas neoplasicas tenian escaso citoplasma, nucleos hendidos e hipercromaticos en conjunto con linfocitos pleomorficos y elevado indice mitotico; tambien se encontro celulas gigantes multinucleadas y necrosis, observandose un variado patron histologico en algunas areas del tejido tumoral (FIGS.