Amsterdam criteria

The clinical criteria needed to diagnose hereditary nonpolyposis colorectal cancer (HNPCC—Lynch syndrome) in a family:
• There are at least three relatives with an HNPCC-associated cancer (large bowel, endometrium, small bowel, ureter or renal pelvis, but not stomach, ovary, brain, bladder or skin);
• One affected person is a first-degree relative of the other two;
• At least two successive generations are affected;
• At least one person was diagnosed before the age of 50 years;
• Familial adenomatous polyposis has been excluded;
• Tumours have been verified by pathologic examination.

Amsterdam criteria

Oncology Criteria for diagnosing hereditary nonpolyposis colorectal cancer, see there.

Amsterdam criteria

Family history: Presence of histologically verified colorectal cancer in ≥ 3 relatives–one of whom is a 1^st-degree relative of the other 2
'Vertical' history: Presence of disease in ≥ 2 successive generations
Age of onset: Age < 50 in > 1 affected relative
Exclusion: Hereditary polyposis syndromes have been excluded

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References in periodicals archive

Families meeting the Amsterdam Criteria but with no identifiable mutation should be labelled as 'familial colorectal cancer syndrome X' and be enrolled into appropriate screening programmes.

Colorectal cancer is common and survival is strongly related to the stage of the disease at diagnosis

Further, ten families of colorectal cancers (11.1%) did not meet all of Amsterdam criteria, but they had colorectal cancers in two generations.

Hereditary nonpolyposis colorectal cancer in Pakistan: Results of a pilot study

Subsequently, we investigated the MLH1 and MSH2 genes of patients fulfilling the Amsterdam criteria prospectively by the BESS protocol.

Identification of germline mutations in hereditary nonpolyposis colorectal cancer using base excision sequence scanning analysis

Amsterdam Criteria Amsterdam Criteria I, 1990 At least 3 relatives with colorectal cancer: 1.

Microsatellite instability and colorectal cancer

Almost half of all patients with HNPCC can be identified through family history, and this fact has been incorporated in two sets of clinical criteria, known as the Bethesda criteria and the modified Amsterdam criteria. The latter is the simpler of the two, recommending genetic testing if these three criteria are met:

Managing colon ca's other genetic risk factors; surveillance key when mutations detected

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